Dovitinib Dilactic Acid( Dovitinib Dilactic acid | TKI258 Dilactic acid | CHIR-258, TKI258 )

Catalog No. M17618 CAS No. 852433-84-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Dovitinib Dilactic Acid
Note

Research use only, not for human use.
Brief Description

Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor.
Description

Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.
In Vitro

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In Vivo

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Synonyms

Dovitinib Dilactic acid | TKI258 Dilactic acid | CHIR-258, TKI258
Pathway

Metabolic Enzyme/Protease
Target

Dehydrogenase
Recptor

c-Kit| FGFR1| FGFR3| FLT3| VEGFR3/FLT4
Research Area

Cancer
Indication

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CAS Number

852433-84-2
Formula Weight

572.59
Molecular Formula

C21H21FN6O·2C3H6O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 30 mg/mL (52.39 mM)
SMILES

CC(C(=O)O)O.CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C/4\C(=C5C(=NC4=O)C=CC=C5F)N)/N3
Chemical Name

2-Hydroxypropanoic acid compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1- piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone

1. Trudel S, et al. Blood. 2005, 105(7), 2941-2948.

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